Nuplazid (pimavanserin)
Nuplazid (pimavanserin) is a medication used for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.
- Disease Indications : Parkinson's Disease
- Manufacturer : ACADIA Pharmaceuticals Inc
- Usage : Oral
Medicine approved by
- Food and Drug Administration (FDA)
Details
What is Nuplazid (pimavanserin) for?
Nuplazid (pimavanserin) is the first medicine approved for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis.
It is available in capsule form each containing 34mg of pimavanserin.
How does Nuplazid (pimavanserin) work?
Hallucinations or delusions can occur in as many as 50% of patients with Parkinson’s disease at some time during the course of their illness.
People who experience them see or hear things that are not there (hallucinations) and/or have false beliefs (delusions). Hallucinations and delusions experienced with Parkinson’s disease are serious symptoms which can lead to impaired thoughts and emotions that may be disturbing and disabling. As a result, patients may not relate to loved ones well or take appropriate care of themselves. The mechanism of action of pimavanserin in the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis is unknown. However, its effect could be mediated through a combination of inverse agonist and antagonist activity at serotonin receptors, which influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation.
Is Nuplazid (pimavanserin) approved?
Nuplazid (pimavanserin) was approved for the treatment of patients with hallucinations and delusions associated with Parkinson’s disease psychosis by:
- Food and Drugs Administration (FDA) (USA) on April 29, 2016
Please note that this medication may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval and availability in a specific country feel free to contact our support team for assistance.
How do I take Nuplazid (pimavanserin)?
The standard dosage is:
- one tablet of 34 mg, taken orally once daily.
Complete information about Nuplazid (pimavanserin) dosage and administration can be found in the references section.
Warning: Nuplazid (pimavanserin) is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis.
Note: Consult your treating doctor for personalised dosing.
Are there any known adverse reactions or side effects of Nuplazid (pimavanserin)?
Common adverse reactions
The most common adverse reactions (≥5% patients) listed in the prescribing information include:
- Peripheral edema
- Confusional state
Serious side effects
The serious adverse reactions listed in the prescribing information include:
- QT interval prolongation (heart rhythm disorder)
Use in a specific population
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. No drug in this class is approved to treat patients with dementia-related psychosis.
Use of Nuplazid (pimavanserin) is not recommended in patients with severe renal impairment and in patients with hepatic impairment.
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.
References
- Summary of Product Characteristics [FDA]: Nuplazid (pimavanserin) [PDF] Acadia Pharmaceuticals Inc., Mar. 2018
- FDA approves first drug to treat hallucinations and delusions associated with Parkinson’s disease FDA, April 2016
- 5-HT receptor Wikipedia, cited March 2017
Clinical trials
The approval was based on a 6-week clinical trial involving 199 participants. In this study, pimavanserin was shown to be superior to placebo in decreasing the frequency and/or severity of hallucinations and delusions without worsening the primary motor symptoms of Parkinson’s disease.
As with other atypical antipsychotic drugs, there is an increased risk of death associated with the use of these drugs to treat older people with dementia-related psychosis. No drug in this class is approved to treat patients with dementia-related psychosis.
References
Price & Costs
Nuplazid (pimavanserin) treatment costs
The cost for a monthly or yearly treatment of Nuplazid (pimavanserin) depends on your prescription requirements which includes the dosage in mg and medicine type (Capsules).
The price of the medicines you see on sale is the cost set by the manufacturer. In addition, shipping costs and a Named Patient support fee will apply.
Make an enquiry and we will help you calculate the total price to buy Nuplazid (pimavanserin) online and have it delivered where you live. From your side, we’ll simply need a prescription from your treating doctor. In some countries we might also need an import license. Our Patient Support team will guide you throughout the process.
Nuplazid (pimavanserin) price and additional costs
- The price of Nuplazid (pimavanserin)
- Our Named Patient support fee
- Shipping costs
- Payment methods when you buy Nuplazid (pimavanserin)
The base cost of each medicine is set by the manufacturer. Generally, our Named Patient support fee, shipping costs and any local tax (if applicable) are not included in the product price that is displayed on our website unless stated otherwise.
everyone.org provides access to Nuplazid (pimavanserin) on the Named Patient import basis, which means that we work on behalf of the patient in cooperation with their treating doctor. Our Named Patient support fee covers sourcing, logistics and following up to make sure that the order is received safely and in perfect condition. The Named Patient support fee is tiered relative to the cost of the medicine.
The shipping prices are dependent on the type of shipping necessary for the particular medicine (regular or cold chain) and upon the destination country. The shipping fees may include the shipping from our supplier to our partner pharmacy as well as the shipping costs to deliver the medicine to the patient’s country of residence. The shipping fee might also include the cost of special packaging, such as coolboxes, cool packs and data loggers, as well as transport insurance to guarantee that you receive your medicine in good order.
When you buy Nuplazid (pimavanserin), you can make the payment by bank transfer or by credit card. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
Nuplazid (pimavanserin) reimbursement
It might be possible for you to claim the cost of Nuplazid (pimavanserin) via your country's healthcare system. Some countries have a government fund providing financial assistance for citizens to access lifesaving medical treatment abroad. The best thing would be to check with your country's own health ministry. We also highly recommend checking out local patient blogs, communities and patient organisations to find out more about your options.
Medical insurance
Generally, we do not support medical insurance, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. In some limited circumstances, we do accept insurance. Contact us for more details. You can pay by bank transfer or credit card.
Crowdfunding
Crowdfunding might also be an option for you. It is a means of raising funds by using an online platform to group together many small donations from friends, family and others, in order to help you afford medical treatment. Here are some crowdfunding platforms where you can seek support: GoFundMe, GiveForward, FundRazr and Watsi.
Shipping
Cold chain shipping
Some medicinal ingredients are susceptible to damage from heat, light and handling. Using "cold chain" delivery, specialised medical couriers have temperature regulated boxes and vehicles to ensure that the medicine is uncompromised. For that reason, cold chain shipping can be more expensive than regular shipping.
Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised cold chain couriers. If you would like your order to be shipped by a specific courier, please inform us when you place the order.
Our standard delivery time varies from 5 to 10 working days.
The shipping cost depends on the medicine and the destination country. After making an enquiry, you will receive a detailed quote that includes the shipping costs.
You can also pick up your medicine from our partner pharmacy in Amsterdam or our partner pharmacy in Luxembourg after the order has been paid for.
Our Process
Four steps to access the medicines you need
How and where to access and buy Nuplazid: You can access Nuplazid from everyone.org if the drug has not been approved or is not available in your country.
- Step 1: You send a request for your medicine online
- Step 2: We verify your prescription and medical details
- Step 3: We source your medicine
- Step 4: We deliver your medicine
Submit a request for a specific medicine, or a general request, and your Patient Support Manager will contact you within 24 hours. They will be there to support and guide you in anyway possible to help you get the medicine you need.
Since we help patients access medicines not available in their home country, our first step is to check that the medicine you need is not currently available in your home country. Next we will also verify that you have a prescription from a doctor in your home country for the medicine you need.
Once we have verified your prescription and medical details, our expert sourcing team will work with our global network of suppliers to find you the best price. Once we have found you the lowest possible cost for your medicine, we will present you with a final offer for your approval.
After you have accepted our offer, our experienced logistics team will arrange all the shipping and transportation of your medicine. We will work hard to keep you informed at every step along the way and get your medicine to you quickly and safely. To date we have successfully delivered packages to over 75 countries around the world.
Contact Patient Support
If you have any questions or need any help, contact our Patient Support Team. We will get in touch with you within 24 hours from Monday to Friday between 9:00 and 10:00 CET.
Email Address
Sshealthcare1012@gmail.com
+91 7575883015
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