Symdeko (Tezacaftor/Ivacaftor & Ivacaftor)
- Medicine Name: Symdeko
- Generic Name: Tezacaftor/Ivacaftor and Ivacaftor
- Dosage Form & Strength: 100 mg/150 mg and 150 mg Tablets; 50 mg/75 mg and 75 mg Tablets
- Manufactured By: Vertex Pharmaceuticals Incorporated
Medical Uses
Symdeko is a fixed dose combination (FDC) of tezacaftor and ivacaftor, used to treat patients with cystic fibrosis (CF) aged 12 years and older who have a couple of copies of the F508del mutation, or who have at least one mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is responsive to Symdeko (tezacaftor/ivacaftor).
If the patient’s genotype is not known, a CF mutation test should be considered in order to detect the existence of a CFTR mutation followed by verification with bi-directional sequencing when required by the mutation test instructions for use.
Recommended Dosage: The recommended dosage for Adults, Adolescents, and Children Aged 12 Years and Older is one tablet (tezacaftor 100 mg/ivacaftor 150 mg) taken in the morning and one tablet (ivacaftor 150 mg) taken in the evening, around 12 hours apart. Medicine Symdeko is for oral use. Patients should completely swallow the tablets. Take with fat-containing food, such as foods or snacks that contain fat and those prepared with oils or butter or those containing cheeses, nuts, eggs, whole milk, or meats.
In case 6 hours or less have passed since the missed or skipped morning or evening dose, the patient should take the missed/skipped dose as promptly as possible and continue on the standard schedule.
In case more than 6 hours have passed since the missed or skipped morning or evening dose, the patient should not take the missed/skipped dose. Take the very next scheduled dose of Symdeko at around the usual time. It is not advisable to take more than a single dose at the same time.
Warning & Precautions
- Elevated transaminases may be observed in those with CF treated with symdeko tablets, as well as with ivacaftor monotherapy. Assessments of ALT and AST are required for all patients before the start of treatment, every 90 days during the first year of treatment, and annually thereafter. For those with a history of transaminase elevations more frequent monitoring is required.
- Exposure to ivacaftor is significantly reduced and exposure to tezacaftor may be decreased by the concomitant administration of CYP3A inducers, which may scale down the therapeutic effectiveness of medicine symdeko. Therefore, do not co-administer this medication with strong CYP3A inducers.
- Cases of non-congenital lens opacities may occur in pediatric patients treated with drug symdeko, as well as with ivacaftor monotherapy. A possible risk attributable to therapy with Tezacaftor/Ivacaftor and Ivacaftor cannot be excluded. Perform baseline and follow-up ophthalmological examinations in pediatric patients starting therapy with Tezacaftor/Ivacaftor and Ivacaftor.
- Do not take (tezacaftor 100 mg/ivacaftor 150 mg) if you take certain medications or herbal supplements such as: antibiotics such as rifabutin (Mycobutin), rifampin (Rifater, Rifamate), seizure medicines such as carbamazepine, phenobarbital (Carbatrol, Tegretol, Equetro), or phenytoin (Phenytek, Dilantin), snd St. John’s wort.
- Symdeko treatment may cause dizziness in some individuals who take it. Avoid driving a car, using machinery, or doing anything that requires full alertness until they know how this medication affects them. Avoid food or drink that contains grapefruit or Seville oranges while on Symdeko treatment.
- The medicine Symdeko should always be taken with a fat-containing food/meal or snack to help the body absorb the medication. Be sure to avoid meals/foods and drinks that are known to contain grapefruit while taking Symdeko because they may be responsible for affecting the existence of Symdeko in the body.
Documentation & Availability
What documents are required to import SYMDEKO to India?
SYMDEKO (tezacaftor/ivacaftor; ivacaftor) tablets, can be imported by patients or government hospitals on the name of the patients only.
The following documentation is required to import the product:
- A valid prescription from a qualified doctor.
- Patient’s diagnostic reports.
- Patient’s ID proof (issued by the Government of India).
How is the order confirmed?
The order will be confirmed only after the receipt of:
- A valid prescription from a doctor.
- Import permit if applicable.
Is SYMDEKO available in India?
SYMDEKO (tezacaftor/ivacaftor; ivacaftor) Tablets, is a (prescription drug, prescription medication or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.
S S Healthcare (S S Healthcare) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input
- On availability in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
- Medicine Price.
- Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
- Ensuring 100% transparency.
SYMDEKO can be made available to patients, doctors and hospitals at Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and import permit.
S S Healthcare (S S Healthcare) can facilitate the supply of SYMDEKO (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement (if applicable)
Please contact +91-7575883015 | Number: +91-7575883015 or write us at sshealthcare1012@gmail.com for Symdeko price in India.
We take guarantee of quality and delivery anywhere in the world as per the buyer’s requirements.
Sourcing & Delivery
S S Healthcare is able to source SYMDEKO (Cancer Treatment Medicines) from across the globe, and has the ability to supply. S S Healthcare offers its customers worldwide access to the best available treatment.
S S Healthcare is able to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.
FAQ
What is the Generic Name for the trade name drug Symdeko®?
Tezacaftor/Ivacaftor and Ivacaftor is Generic Name for the trade name drug Symdeko®.
What is the Manufacturer Name of Symdeko®?
Symdeko® is manufactured by Vertex Pharmaceuticals Incorporated.
Is Symdeko® approved by the FDA?
Yes, Symdeko® is approved by the FDA. Date of approval: February 12, 2018.
Where can I get Symdeko® at the best price in India?
To get the best Symdeko price in India, contact S S Healthcare (a WHO-GDP & ISO 9001:2008 authorized Company). A valid medical prescription is required while buying Symdeko®.
What is the dosage and form of Symdeko® supplied?
Symdeko® is co-packaged as tezacaftor 100 mg/ivacaftor 150 mg fixed dose combination tablets and ivacaftor 150 mg tablets which are supplied for oral administration.
How is Symdeko® packaged?
Each box of medicine Symdeko mainly contains 4 weekly wallets. Each weekly wallet typically contains 14 tablets.
What are the most common side effects with Symdeko®?
The most common side effects with Symdeko are: sinus congestion, headache, nausea, and dizziness.
How much does Symdeko® cost in India?
The cost of symdeko in India is less and can vary. In order to procure this cystic fibrosis (CF) medicine authentically, you can Call or WhatsApp +91-7575883015 or send mail to sshealthcare1012@gmail.com.
What are the storage conditions of Symdeko®?
Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).
Is it safe to buy Symdeko® online from India?
Yes, You can buy Symdeko online in India at the best price from the S S Healthcare if Symdeko® has not been approved or is not available in your country.
What are the Highlights of prescribing information for Symdeko®?
Click Here to download full Symdeko prescribing information.
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