Details

What is Tavneos (avacopan) for?

Tavneos (avacopan) is a selective complement 5a receptor inhibitor indicated for use with other medicines (such as glucocorticoids) to treat adults with severe active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) (granulomatosis with polyangiitis [GPA], formerly known as Wegener’s granulomatosis, and microscopic polyangiitis [MPA]).

It does not eliminate the need for use of glucocorticoids.

It is available in capsule form, each containing 10 mg of avacopan.

How does Tavneos (avacopan) work?

AAV is a rare autoimmune disorder in which the body’s immune system attacks small blood vessels. This causes organ damage and failure, especially the kidneys. Currently, AAV is treated with a combination of medications, including glucocorticoids, which can have toxic effects when used for prolonged periods of time.

AAV occurs when the complement pathway is activated, leading to production of the protein complement 5a (C5a). The active ingredient in Tavneos, avacopan, blocks the effects of C5a through the C5a receptor. This is expected to help reduce blood vessel inflammation and improve symptoms.

Where has Tavneos (avacopan) been approved?

Tavneos (avacopan) was approved for the treatment of AAV by:

Tavneos (avacopan) received Orphan Drug Designation for the treatment of AAV and for C3 glomerulopathy (C3G).

Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.

How is Tavneos (avacopan) taken?

The standard dosage is:

If you miss a dose of Tavneos, do not take the missed dose. Just take the next dose at your regular time. Do not double the next dose.

Before starting with treatment, your liver function will be evaluated and you will be tested for Hepatitis B (HBV).

Do not use Tavenos together with strong and moderate CYP3A4 enzyme inducers. Reduce the to 30 mg once daily when using together with CYP3A4 inhibitors.

Complete information about Tavneos (avacopan) dosage (modifications) and administration can be found in the official prescribing information listed in our references section.

Note: Please consult with your treating doctor for personalised dosing.

Are there any known adverse reactions or side effects of Tavneos (avacopan)?

Common adverse reactions

The most common side effects (≥5% of patients) listed in the prescribing information include:

Serious adverse reactions

The serious adverse reactions listed in the prescribing information include:

Use in a specific population

It is not known if Tavneos (avacopan) will harm your unborn baby or if it passes into your breast milk Talk to your treating doctor if you are pregnant or planning to become pregnant, or about the best way to feed your baby while taking this medicine.

Tavneos is not recommended for patients with active, untreated and/or uncontrolled chronic liver disease (e.g., hepatitis B, hepatitis C, autoimmune hepatitis) and cirrhosis. Discuss the risk and benefit with your treating doctor before starting treatment.

For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.

References

Clinical trials

The Food and Drug Administration (FDA) approval of Tavneos (avacopan) for the treatment of adults with severe active anti-neutrophil cytoplasmic autoantibody-associated (ANCA) vasculitis (AAV) was based on data of the ADVOCATE trial (NCT02994927).

ADVOCATE was a phase 3, randomized, controlled trial that involved 330 patients AAV. Patients received oral Tavneos 30 mg twice daily or oral glucocorticoids for 52 weeks. All the patients received either cyclophosphamide/azathioprine or rituximab.

Results

The main study endpoints were the proportion of patients achieving disease remission at 26 weeks and sustained remission at 52 weeks.

Tavneos showed to be superior to prednisone after 1 year of treatment:

Please refer to the summary of product characteristics below and in the resource section for comprehensive information about the safety and effectiveness of Tavneos (avacopan) for the approved indication.

References

Price & Costs

Kevzara (sarilumab) price in other currencies*

Package	Euro	Australian dollars	Canadian dollar	New Zealand dollar	Nigerian naira	Singapore dollar	Pound sterling	United States dollar
30 capsules of 10 mg	1986 EUR	3279 AUD	2963 CAD	3607 NZD	3299796 NGN	2805 SGD	1637 GBP	2092 USD
180 capsules of 10 mg	11543 EUR	19056 AUD	17224 CAD	20965 NZD	19175979 NGN	16305 SGD	9516 GBP	12157 USD

*The prices listed above are based on the cheapest package size and strength everyone.org has access to. Please make an enquiry for more specific pricing. The prices listed above are a guide only, we operate in Euros.

Tavneos (avacopan) treatment costs

The cost for a monthly or yearly treatment of Tavneos (avacopan) depends on your prescription requirements which includes the dosage in mg and medicine type (Capsules).

The price of the medicines you see on sale is the cost set by the manufacturer. In addition, shipping costs and a Named Patient support fee will apply.

Make an enquiry and we will help you calculate the total price to buy Tavneos (avacopan) online and have it delivered where you live. From your side, we’ll simply need a prescription from your treating doctor. In some countries we might also need an import license. Our Patient Support team will guide you throughout the process.

Tavneos (avacopan) price and additional costs

Tavneos (avacopan) reimbursement

It might be possible for you to claim the cost of Tavneos (avacopan) via your country's healthcare system. Some countries have a government fund providing financial assistance for citizens to access lifesaving medical treatment abroad. The best thing would be to check with your country's own health ministry. We also highly recommend checking out local patient blogs, communities and patient organisations to find out more about your options.

Medical insurance

Generally, we do not support medical insurance, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. In some limited circumstances, we do accept insurance. Contact us for more details. You can pay by bank transfer or credit card.

Crowdfunding

Crowdfunding might also be an option for you. It is a means of raising funds by using an online platform to group together many small donations from friends, family and others, in order to help you afford medical treatment. Here are some crowdfunding platforms where you can seek support: GoFundMe, GiveForward, FundRazr and Watsi.

Shipping

Room temperature shipping

For this medication, standard shipping applies. This means that a consistent room temperature of 15 to 25°C is maintained during transit.

Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised cold chain couriers. If you would like your order to be shipped by a specific courier, please inform us when you place the order.

Our standard delivery time varies from 5 to 10 working days.

The shipping cost depends on the medicine and the destination country. After making an enquiry, you will receive a detailed quote that includes the shipping costs.

You can also pick up your medicine from our partner pharmacy in Amsterdam or our partner pharmacy in Luxembourg after the order has been paid for.

Our Process

Four steps to access the medicines you need

How and where to access and buy Tavneos: You can access Tavneos from everyone.org if the drug has not been approved or is not available in your country.