Trikafta (elexacaftor, tezacaftor and ivacaftor)
- Medicine Name: Trikafta
- Generic Name: Elexacaftor/Tezacaftor/Ivacaftor and Ivacaftor
- Dosage Form & Strength: Tablets: 100mg/50mg/75mg and 150mg, 50mg/25mg/37.5mg and 75mg
- Manufactured By: Vertex Pharmaceuticals Incorporated.
Medical Uses
Trikafta is a combination of ivacaftor, a CFTR potentiator, tezacaftor, and elexacaftor used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one F508del mutation in the CFTR gene or a mutation in the CFTR gene that is responsive.
Recommended Dosage: The recommended morning and the evening dose should be taken orally approximately 12 hours apart. Swallow tablets whole. The trikafta tablets should be taken with fat-containing food. Examples of snacks or meals that contain fat are those prepared with oils, or butter or those containing cheeses, eggs, nuts, whole milk, or meats.
Recommended Dosage for Adult and Pediatric Patients aged 6 to less than 12 years weighing less than 30 kgs:
- Morning Dose: Two tablets, each containing elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mg.
- Evening Dose: One tablet of ivacaftor 75 mg
Recommended Dosage for Adult and Pediatric Patients aged 6 to less than 12 years weighing 30 kgs or more:
- Morning Dose: Two tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg
- Evening Dose: One tablet of ivacaftor 150 mg
Recommended Dosage for Adult and Pediatric Patients aged 12 years and older:
- Morning Dose: Two tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg
- Evening Dose: One tablet of ivacaftor 150 mg
In case 6 or less hours have passed since the missed or skipped morning or evening dose, the patient should take the missed dose as promptly as possible and continue on the original schedule.
In case more than 6 hours have passed since:
The missed/skipped morning dose, the patient should take the missed/skipped dose as promptly as possible and should not take the evening dose. The next scheduled morning dose needs to be taken at around the usual time.
The missed/skipped evening dose, the patient should not take the missed/skipped dose. The next scheduled morning dose needs to be taken at around the usual time.
Morning and evening doses must not be taken at the same time.
Warning & Precautions
- Elevated transaminases have been observed in patients with trikafta cystic fibrosis medicine. Bilirubin elevations have also been seen with this treatment. Assessments of ALT, AST, and bilirubin are recommended for all patients before initiating Trikafta, every three months during the first year of therapy, and annually thereafter.
- Exposure to ivacaftor is significantly decreased and exposure to elexacaftor and tezacaftor are expected to decrease by the concomitant use of strong CYP3A inducers, which may scale down the therapeutic effectiveness of drug Trikafta. Therefore, use of this medication with strong CYP3A inducers is not recommended.
- Exposure to elexacaftor 50 mg, tezacaftor 25 mg and ivacaftor 37.5 mg are increased when used together with strong/moderate CYP3A inhibitors. Therefore, the dosage of Trikafta needs to be reduced when used concomitantly with moderate/strong CYP3A inhibitors.
- Cases of non-congenital lens opacities have been seen in pediatric patients treated with ivacaftor-containing regimens. Although other risk factors existed in some cases (such as corticosteroid use, exposure to radiation), a possible risk attributable to therapy with ivacaftor cannot be excluded. Follow-up ophthalmological examinations are required in pediatric patients initiating therapy with Trikafta.
Documentation & Availability
What documents are required to import TRIKAFTA to India?
TRIKAFTA (elexacaftor, tezacaftor, and ivacaftor) tablets can be imported by patients or government hospitals on the name of the patients only.
The following documentation is required to import the product:
- A valid prescription from a qualified doctor.
- Patient’s diagnostic reports.
- Patient’s ID proof (issued by the Government of India).
How is the order confirmed?
The order will be confirmed only after the receipt of:
- A valid prescription from a doctor.
- Import permit if applicable.
Is TRIKAFTA available in India?
TRIKAFTA (elexacaftor/tezacaftor/ivacaftor tablet) is a (prescription drug, prescription medication or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.
S S Healthcare (S S Healthcare) helps import cancer medicines on the named patient supply (NPS). Indian Pharma Network is the facilitator providing input
- On availability in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Pune etc.)
- On availability in Gulf countries (Bahrain, Oman, Qatar, Kuwait, Iraq, Saudi Arabia, and the UAE).
- Medicine Price.
- Finding Genuine and reliable sources from the USA, Canada, Europe, and Australia
- Ensuring 100% transparency.
TRIKAFTA can be made available to patients, doctors and hospitals at Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow and Pune and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and import permit.
S S Healthcare (S S Healthcare) can facilitate the supply of TRIKAFTA (prescription medicines) to all locations in the world and in India after fulfilling the legal requirement (if applicable)
Please contact +91-7575883015 | Toll-Free No: +91-7575883015 or write us at sshealthcare1012@gmail.com for trikafta tablet price in India.
We take guarantee of quality and delivery anywhere in the world as per the buyer’s requirements.
Sourcing & Delivery
S S Healthcare is able to source the TRIKAFTA (Cancer Treatment Medicines) from across the globe, and has the ability to supply. S S Healthcare offers its customers worldwide access to the best available treatment.
S S Healthcare is able to dispense any valid prescription in the shortest possible time. All prescriptions are dispensed and checked by registered pharmacists and dispatched to the Patient’s address only from New Delhi, India.
FAQ
What is the Generic Name for the trade name drug Trikafta®?
Elexacaftor/Ivacaftor/Tezacaftor is Generic Name for the trade name drug Trikafta®.
What is the Manufacturer Name of Trikafta®?
Trikafta® is manufactured by Vertex Pharmaceuticals Incorporated.
Is Trikafta® approved by the FDA?
Yes, Trikafta® is first approved by the FDA. Date of approval: October 21, 2019.
Where has Trikafta® been approved?
This medication has received regulatory approval in 32 nations, 27 within the EMA centralized regulatory approval in addition to receiving approval in the United States (US), United Kingdom (UK), Liechtenstein, Norway, and Iceland.
What is the dosage and form of Trikafta® supplied?
Trikafta® is supplied as a fixed-dose combination drug containing elexacaftor, tezacaftor, and ivacaftor co-packaged with ivacaftor for oral administration.
What are the most common side effects due to Trikafta®?
Most common trikafta side effects may include: influenza, headache, upper respiratory tract infection, abdominal pain, diarrhea, alanine aminotransferase increased, nasal congestion, rhinorrhea, rhinitis, sinusitis, rash and blood bilirubin increased.
How much does Trikafta® cost in India?
The trikafta cost in India is very reasonable and can vary. In order to procure this Cystic fibrosis (CF) medication authentically, you can call or WhatsApp +91-7575883015 or send mail to sshealthcare1012@gmail.com.
What are the storage conditions of Trikafta®?
Store at 68 to 77°F (20 to 25°C); excursions permitted to 59 to 86°F (15 to 30°C). Do not use this medicine after the expiration date mentioned on the package.
Is it safe to buy Trikafta® online in India?
Yes, You can buy trikafta tablets online in India authentically from https://www.indianpharmanetwork.in/ if Trikafta has not been approved or is not available in your country.
Is S S Healthcare certified by WHO-GDP and ISO 9001:2008 authorities?
Yes, We have certification from the top-most authorities like WHO-GDP and ISO 9001:2008. We’re the leading Supplier and Wholesaler of Trikafta in India. We can help you to get this Cystic Fibrosis (CF) medicine at the lowest affordable price.
What are the Highlights of prescribing information for Trikafta®?
Click Here to download full Trikafta prescribing information.
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