Ubrelvy (ubrogepant)
Ubrelvy (ubrogepant) is a medication used in adults for the acute treatment of migraine headaches with or without aura.
- Disease Indications : Migraine
- Manufacturer : Allergan USA
- Usage : Oral
Medicine approved by
- Food and Drug Administration (FDA)
Details
What is Ubrelvy (ubrogepant) for?
Ubrelvy (ubrogepant) is a calcitonin gene-related peptide (CGRP) receptor antagonist indicated for the acute treatment of migraine headaches with or without aura.
It will not prevent migraine headache.
It is available in tablet form containing 50 mg or 100 mg ubrogepant.
How does Ubrelvy (ubrogepant) work?
Ubrogepant is a monoclonal antibody, a type of protein, that blocks the activity of the calcitonin gene-related peptide (CGRP) receptor. CGRP is a molecule that is involved in migraine attacks. When its levels go up, it triggers intense inflammation in the brain, causing migraine headaches.[2] By blocking the CGRP receptor, ubrogepant can relieve pain experienced during attacks.
It works without causing constriction in the blood vessels, which some older treatments are known to do.
Where has Ubrelvy (ubrogepant) been approved?
Ubrelvy (ubrogepant) was approved for the acute treatment of adults with migraine by:
- The Food and Drug Administration (FDA), USA, on December 23, 2019.
It is the first and only CGRP receptor antagonist that can be taken orally for the treatment of migraine attacks.
Please note that this medicine may have also been approved in other regions than the ones we’ve listed. If you have a question about its approval in a specific country feel free to contact our support team.
How is Ubrelvy (ubrogepant) taken?
The standard dosage is:
- 50 mg or 100 mg taken orally, as needed
- A second dose may be administered at least 2 hours after the initial dose for pain relief.
The maximum dose in a 24 hour period is 200 mg.
Because there is a risk of drug interactions, this medicine should not be used with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin).
The dose of Ubrelvy (ubrogepant) should be modified when it is used together with specific drugs and for patients with liver (hepatic) or kidney (renal) impairment.
Complete information about Ubrelvy (ubrogepant) dosage and administration can be found in the official prescribing information listed in our references section.
Note: Please consult with your treating doctor for personalised dosing.
Are there any known adverse reactions or side effects of Ubrelvy (ubrogepant)?
Common adverse reactions
The most common side effects (1-10% of patients) listed in the prescribing information include:
- Nausea
- Tiredness (fatigue)
- Dry mouth
Use in a specific population
Ubrelvy (ubrogepant) can cause fetal harm when administered to a pregnant woman, it is advised to avoid pregnancies and breastfeeding.
For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.
References
- Full prescribing information [FDA]: Ubrelvy (ubrogepant) [PDF] Allergan, Dec 23, 2019
- What to Know About the New Anti CGRP Migraine Treatment Options American Migraine Foundation, last checked on Aug 20, 2020
- Ubrogepant for the Treatment of Migraine Dodick DW, New England Journal of Medicine, Dec 5, 2019
- FDA approves new treatment for adults with migraine FDA press release, Dec 23, 2019
Clinical trials
The Food and Drugs Administration (FDA) approval of Ubrelvy (ubrogepant) for the acute treatment of adults with migraine with or without aura was based on the data of study ACHIEVE I (NCT02828020) and study ACHIEVE II (NCT02867709).
ACHIEVE I and ACHIEVE II were multicenter, randomized, double‐blind, parallel‐group, single‐attack trials in adults with migraine. The trials studied the efficacy, safety, and tolerability of ubrogepant compared to placebo for the acute treatment of a single migraine attack.
ACHIEVE I involved 1672 participants who received either ubrogepant 50 mg or 100 mg or matching placebo.[2] ACHIEVE II involved 1686 participants who received either ubrogepant 25 mg or 50 mg or matching placebo.
Participants took 1 or 2 tablets of medicine or placebo as soon as possible within 4 hours of the onset of a migraine attack.
Data from the ubrogepant 50 mg and placebo groups of the 2 trials were pooled during the analysis after the trials.
Results
The main efficacy outcomes were pain freedom (defined as a reduction in headache severity from moderate or severe pain to no pain) and absence of the most bothersome migraine-associated symptoms (nausea, light sensitivity or sound sensitivity) at 2 hours after taking the medicine. These parameters were being recorded by the participants in an electronic diary.
In both studies, the percentages of patients achieving pain freedom and whose most bothersome migraine symptoms stopped 2 hours after taking the medicine were significantly greater among patients receiving ubrogepant compared to those receiving placebo.
Please refer to the summary of product characteristics below and in the resource section for comprehensive information about the safety and effectiveness of Ubrelvy (ubrogepant) for the approved indication.
References
- Full prescribing information [FDA]: Ubrelvy (ubrogepant) [PDF] Allergan, Dec 23, 2019
- Efficacy, Safety, and Tolerability Study of Oral Ubrogepant in the Acute Treatment of Migraine (ACHIEVE I) Clinical Trial (NCT02828020), cited on Nov 10, 2020
- Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine (ACHIEVE II) Clinical Trial (NCT02867709), cited on Nov 10, 2020
- Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine Lipton RB, JAMA, Nov 19, 2019
- Ubrogepant, an Acute Treatment for Migraine, Improved Patient‐Reported Functional Disability and Satisfaction in 2 Single‐Attack Phase 3 Randomized Trials, ACHIEVE I and II Dodick DW, Headache, Apr 2020
Price & Costs
Nurtec ODT (rimegepant) price in other currencies*
| Package | Euro | Australian dollars | Canadian dollar | New Zealand dollar | Nigerian naira | Singapore dollar | Pound sterling | United States dollar |
|---|---|---|---|---|---|---|---|---|
| 10 tablets of 50 mg | 2047 EUR | 3380 AUD | 3054 CAD | 3718 NZD | 3401149 NGN | 2892 SGD | 1687 GBP | 2156 USD |
| 10 tablets of 100 mg | 2047 EUR | 3380 AUD | 3054 CAD | 3718 NZD | 3401149 NGN | 2892 SGD | 1687 GBP | 2156 USD |
*The prices listed above are based on the cheapest package size and strength everyone.org has access to. Please make an enquiry for more specific pricing. The prices listed above are a guide only, we operate in Euros.
Ubrelvy (ubrogepant) treatment costs
The cost for a monthly or yearly treatment of Ubrelvy (ubrogepant) depends on your prescription requirements which includes the dosage in mg and medicine type (Tablets).
The price of the medicines you see on sale is the cost set by the manufacturer. In addition, shipping costs and a Named Patient support fee will apply.
Make an enquiry and we will help you calculate the total price to buy Ubrelvy (ubrogepant) online and have it delivered where you live. From your side, we’ll simply need a prescription from your treating doctor. In some countries we might also need an import license. Our Patient Support team will guide you throughout the process.
Ubrelvy (ubrogepant) price and additional costs
- The price of Ubrelvy (ubrogepant)
- Our Named Patient support fee
- Shipping costs
- Payment methods when you buy Ubrelvy (ubrogepant)
The base cost of each medicine is set by the manufacturer. Generally, our Named Patient support fee, shipping costs and any local tax (if applicable) are not included in the product price that is displayed on our website unless stated otherwise.
everyone.org provides access to Ubrelvy (ubrogepant) on the Named Patient import basis, which means that we work on behalf of the patient in cooperation with their treating doctor. Our Named Patient support fee covers sourcing, logistics and following up to make sure that the order is received safely and in perfect condition. The Named Patient support fee is tiered relative to the cost of the medicine.
The shipping prices are dependent on the type of shipping necessary for the particular medicine (regular or cold chain) and upon the destination country. The shipping fees may include the shipping from our supplier to our partner pharmacy as well as the shipping costs to deliver the medicine to the patient’s country of residence. The shipping fee might also include the cost of special packaging, such as coolboxes, cool packs and data loggers, as well as transport insurance to guarantee that you receive your medicine in good order.
When you buy Ubrelvy (ubrogepant), you can make the payment by bank transfer or by credit card. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
Ubrelvy (ubrogepant) reimbursement
It might be possible for you to claim the cost of Ubrelvy (ubrogepant) via your country's healthcare system. Some countries have a government fund providing financial assistance for citizens to access lifesaving medical treatment abroad. The best thing would be to check with your country's own health ministry. We also highly recommend checking out local patient blogs, communities and patient organisations to find out more about your options.
Medical insurance
Generally, we do not support medical insurance, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. In some limited circumstances, we do accept insurance. Contact us for more details. You can pay by bank transfer or credit card.
Crowdfunding
Crowdfunding might also be an option for you. It is a means of raising funds by using an online platform to group together many small donations from friends, family and others, in order to help you afford medical treatment. Here are some crowdfunding platforms where you can seek support: GoFundMe, GiveForward, FundRazr and Watsi.
Shipping
Room temperature shipping
For this medication, standard shipping applies. This means that a consistent room temperature of 15 to 25°C is maintained during transit.
Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised cold chain couriers. If you would like your order to be shipped by a specific courier, please inform us when you place the order.
Our standard delivery time varies from 5 to 10 working days.
The shipping cost depends on the medicine and the destination country. After making an enquiry, you will receive a detailed quote that includes the shipping costs.
You can also pick up your medicine from our partner pharmacy in Amsterdam or our partner pharmacy in Luxembourg after the order has been paid for.
Our Process
Four steps to access the medicines you need
How and where to access and buy Ubrelvy: You can access Ubrelvy from everyone.org if the drug has not been approved or is not available in your country.
- Step 1: You send a request for your medicine online
- Step 2: We verify your prescription and medical details
- Step 3: We source your medicine
- Step 4: We deliver your medicine
Submit a request for a specific medicine, or a general request, and your Patient Support Manager will contact you within 24 hours. They will be there to support and guide you in anyway possible to help you get the medicine you need.
Since we help patients access medicines not available in their home country, our first step is to check that the medicine you need is not currently available in your home country. Next we will also verify that you have a prescription from a doctor in your home country for the medicine you need.
Once we have verified your prescription and medical details, our expert sourcing team will work with our global network of suppliers to find you the best price. Once we have found you the lowest possible cost for your medicine, we will present you with a final offer for your approval.
After you have accepted our offer, our experienced logistics team will arrange all the shipping and transportation of your medicine. We will work hard to keep you informed at every step along the way and get your medicine to you quickly and safely. To date we have successfully delivered packages to over 75 countries around the world.
Contact Patient Support
If you have any questions or need any help, contact our Patient Support Team. We will get in touch with you within 24 hours from Monday to Friday between 9:00 and 10:00 CET.
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Sshealthcare1012@gmail.com
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